2',4'-Dihydroxy-2-phenylacetophenone Property

Melting point:

112-116 °C(lit.)

Boiling point:

225°C/10mmHg(lit.)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

7.74±0.35(Predicted)

color 

White to Light yellow to Light orange

CAS DataBase Reference

3669-41-8(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Dihydroxyphenylbenzyl ketone(3669-41-8)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HS Code 

29145000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2',4'-Dihydroxy-2-phenylacetophenone Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline powder

Uses

1-(2,4-Dihydroxyphenyl)-2-phenylethanone is used in preparation of substituted pyrazoles, pyrimidines, triazoles and related heterocycles as c-MYC targeting agents for treatment of cancer and other proliferative diseases.

Preparation

Preparation by Friedel–Crafts acylation of resorcinol with phenylacetyl chloride in the presence of aluminium chloride,
? in methylene chloride (85%) ;
? in nitrobenzene at 70–80° for 15 min (<80%), at r.t. for 24 h (63%) or for 2 days (60%);
? in ethyl ether at r.t. for 24 h (43%).